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Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population

✍ Scribed by Marisol López; Jorge Guerrero; Petra Yescas; Marie-Catherine Boll; Itziar Familiar; Adriana Ochoa; Astrid Rasmussen; María Elisa Alonso

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
82 KB
Volume
22
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025). © 2006 Movement Disorder Society

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