Apolipoprotein E ε4 allele is not associated with the cognitive impairment in community-dwelling normal elderly individuals
✍ Scribed by K. W. Kim; J. C. Youn; J. H. Jhoo; D. Y. Lee; K. U. Lee; J. H. Lee; J. I. Woo
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 63 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0885-6230
- DOI
- 10.1002/gps.664
No coin nor oath required. For personal study only.
✦ Synopsis
Objectives:
The aim of this study was to examine whether the apoe epsilon 4 allele also confers a risk for the cognitive impairment in normal aging.
Methods:
We administered all the eight neuropsychological tests from the cerad neuropsychological battery to the cvd-free, community-dwelling normal elderly individuals, and compared their performance by the occurrence of the apoe epsilon 4 allele.
Results:
Either the impact of apoe epsilon 4 allele itself or its interaction terms with age and gender of the subjects did not influence the performance of the eight neuropsychological tests (epsilon p > 0.1 by ancova).
Conclusions:
The apoe epsilon 4 allele is not a risk factor for the cognitive decline in normal elderly individuals regardless of age and gender.