Apolipoprotein E in Southern Italy: protective effect of ε2 allele in early- and late-onset sporadic Alzheimer's disease
✍ Scribed by Francesco Panza; Vincenzo Solfrizzi; Francesco Torres; Franco Mastroianni; Anna Maria Colacicco; Anna Maria Basile; Cristiano Capurso; Alessia D'Introno; Angelo Del Parigi; Antonio Capurso
- Book ID
- 117471098
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 88 KB
- Volume
- 292
- Category
- Article
- ISSN
- 0304-3940
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A strong association has been described in cross-sectional studies between the ~4 allele of the apolipoprotein E and late-onset Alzheimer's disease (LOAD). This study addresses the relationship between disease progression and the ~4 allele in 6 2 sporadic LOAD (onset at age 70 and over) patients. Di
We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 313 genot