Apolipoprotein e genotype and late paraphrenia

✍ Scribed by Robert Howard; John Dennehey; Simon Lovestone; Joseph Birkett; Pak Sham; John Powell; David Castle; Robin Murray; Raymond Levy

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 304 KB
• Volume: 10
• Category: Article
• ISSN: 0885-6230
• DOI: 10.1002/gps.930100210

✦ Synopsis

Patients with late paraphrenia or late onset schizophrenia frequently have associated cognitive impairment which may in some cases progress to a recognized dementia. The frequency of the apoE ~4 allele is high in individuals who develop Alzheimer's disease. Twenty-three patients with late paraphrenia were genotyped for ApoE. The frequency of the ~4 allele was comparable with that found in a large group of centenarians, but lower than previously reported from populations of normal controls and Alzheimer's disease patients. Two out of three male patients tested had the rare ~2 / ~2 genotype, which was not found in any of the females.

KEY woms-Late paraphrenia, apolipoprotein E.

Apolipoprotein E (ApoE) is a polymorphic protein involved in the transport of cholesterol in myelin and neuronal membranes and is encoded by a gene with three common alleles: ~2 , ~3 and ~4 (Mahley, 1988). ApoE is found in the brain and may be associated with senile plaques. An increased frequency of the ~4 allele of ApoE among patients with Alzheimer's disease has recently been reported (Hardy