## Dear Editor I write in response to some of the issues raised by Roth and Kay in their recent review of late paraphrenia (LP) in the Journal (1998; 13: 775Β± 784). The review provides a useful update on LP, including modern epidemiological, neurposychological, brain imaging and postmortem studies
Late paraphrenia and ICD 10
β Scribed by Marie Quintal; Diana Day-Cody; Prof. Raymond Levy
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 465 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0885-6230
No coin nor oath required. For personal study only.
β¦ Synopsis
As part of a field study of the latest draft of WHO'S ICD 10 classification, two clinicians, one familiar with ICD 9 and one with DSM-111, rated 36 cases previously diagnosed as 'late paraphrenia' using ICD 9. When raters adhered closely to the diagnostic guidelines issued with the new classification, complete agreement was achieved and most cases received a diagnosis of paranoid schizophrenia. However, both raters were uncomfortable with the low threshold for this diagnosis and when freed from the need to give primacy to schizophrenia preferred a much wider range of diagnoses which included a number of subcategories of delusional disorder. 'Persistent delusional disorder' and 'other persistent delusional disorder' produced the best fit but up to eight cases were given two diagnoses. Levels of confidence in the diagnosis and ease of achieving this are also given. There was an acceptable level of agreement (kappa = 0.756) when this procedure was employed. It is argued that retrieval of such cases would be facilitated either by providing a code for age of onset or by restoring a separate category for late onset schizophrenia or late paraphrenia.
KEY wows-Classification, ICD 10, paraphrenia. Kraepelin ( 1919) is generally credited with having established the diagnosis of paraphrenia as a disorder characterized by paranoid delusions, hallucinations and a lack of progressive deterioration. The concept is in fact much older and figures largely in French psychiatry where the term de'lire hallucinatoire chronique persists in current classifications (Pichot, 1982). Mayer-Gross (1932), however, in a follow-up of Kraepelin's original cases, found that in the majority the diagnosis had been changed to schizophrenia and that it was difficult to predict in which patients this could happen.
After Kraepelin's time, the term fell into decline and only reentered the psychiatric vocabulary when Roth (1955) described a group of conditions occurring after the age of 60 in which there was 'a well organized system of paranoid delusions with or without auditory hallucinations existing in the setting of a well-preserved personality and affective response'. This terminology was not easily accepted, opposition arising on the one hand from those who regarded all non-affective paranoid illnesses in old age as early forms of dementia and on the other from those like Frank Fish (1960), who, summarizing the early German literature, claimed to show that what was being described was Requests for reprints to Professor Raymond Levy.
π SIMILAR VOLUMES
KEY woms-Late paraphrenia, review. Roth and Morrissey (1952) adopted the term 'late paraphrenia' to describe 'a specific group of elderly patients with a well organised system of paranoid delusions and hallucinations, existing in the setting of a well preserved personality and affective response'. T
Patients with late paraphrenia or late onset schizophrenia frequently have associated cognitive impairment which may in some cases progress to a recognized dementia. The frequency of the apoE ~4 allele is high in individuals who develop Alzheimer's disease. Twenty-three patients with late paraphreni
## Abstract This is a report of a clinical case presentation from the Neuropsychiatry Conference held at Fulbourn Hospital, Cambridge on March 13, 1992. The conference, chaired by Dr Nigel Hymas, was asked to comment on the diagnosis of a case first referred during September 1990. A 60βyearβold man
We report a 3.7 year follow-up study carried out on 42 patients with an original diagnosis of late paraphrenia who had had a CT scan and simple tests of cognition in addition to an assessment by means of the Geriatric Mental State Schedule. Mortality was found to be no different than in a control gr
Using Kraepelin's distinction between paraphrenia and paranoia, 2 1 patients with late paraphrenia were compared with 12 with late-onset paranoia. The paranoia group had significantly more clinically unsuspected (silent) cerebral infarction on CT brain scan and was less responsive to antipsychotic m