ApoE genotype and Down's syndrome
β Scribed by John Hardy; Richard Crook; Robert Perry; Ravi Raghavan; Gareth Roberts
- Book ID
- 118554057
- Publisher
- The Lancet
- Year
- 1994
- Tongue
- English
- Weight
- 325 KB
- Volume
- 343
- Category
- Article
- ISSN
- 0140-6736
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## Abstract ## Objective Virtually all adults with Down syndrome (DS) have neuropathological manifestations of Dementia in Alzheimer's disease (DAD) but not all develop clinical psychopathology. The effect of allelic variants of Apolipoprotein (APOE) gene in development and progression of DAD and
The relationship between apo E genotypes and risk of dementia in Down syndrome is not clear. Accordingly, we have analysed this locus in 20 demented and 25 nondemented individuals with Down syndrome and combined these data with other studies in a meta-analysis. The meta-analysis revealed an estimate