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Apo E genotypes and risk of dementia in Down syndrome

✍ Scribed by Rubinsztein, D.C.; Hon, J.; Stevens, F.; Pyrah, I.; Tysoe, C.; Huppert, F.A.; Easton, D.F.; Holland, A.J.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 15 KB
Volume: 88
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19990820)88:4<344::aid-ajmg10>3.0.co;2-1

No coin nor oath required. For personal study only.

✦ Synopsis

The relationship between apo E genotypes and risk of dementia in Down syndrome is not clear. Accordingly, we have analysed this locus in 20 demented and 25 nondemented individuals with Down syndrome and combined these data with other studies in a meta-analysis. The meta-analysis revealed an estimated odds ratio for dementia of 2.74 (95% CI 1.34-5.58) (P = .0004) for apo 4 carriers compared with apo 3/3, similar to that observed in late-onset Alzheimer's disease. An additional parallel with lateonset Alzheimer's disease was shown by the apo 2 allele, which was associated with decreased dementia risk in Down syndrome (odds ratio for apo 2/2 + 2/3 = 0.37 (95% CI 0.14-0.96)). Thus, apo E genotypes are associated with similar risk effects in Down syndrome dementia and late-onset Alzheimer's disease.

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