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APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk

✍ Scribed by Onofre Combarros; Eloy Rodríguez-Rodríguez; Ignacio Mateo; José Luis Vázquez-Higuera; Jon Infante; José Berciano; Pascual Sánchez-Juan

Book ID
116781528
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
417 KB
Volume
32
Category
Article
ISSN
0197-4580

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## Abstract A number of studies suggest that brain cholesterol metabolism may play a role in Alzheimer's disease (AD) development, probably through modulation of amyloid beta production. The discovery that apolipoprotein E (__APOE__) ε4 allele is a risk factor for sporadic AD raises the possibility