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Association of genetic variants of ABCA1 with Alzheimer's disease risk

✍ Scribed by Eloy Rodríguez-Rodríguez; Ignacio Mateo; Javier Llorca; Coro Sánchez-Quintana; Jon Infante; Inés García-Gorostiaga; Pascual Sánchez-Juan; José Berciano; Onofre Combarros


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
77 KB
Volume
144B
Category
Article
ISSN
1552-4841

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✍ Eloy Rodríguez; Ignacio Mateo; Javier Llorca; Coro Sánchez-Quintana; Jon Infante 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 59 KB 👁 1 views

## Abstract A number of studies suggest that brain cholesterol metabolism may play a role in Alzheimer's disease (AD) development, probably through modulation of amyloid beta production. The discovery that apolipoprotein E (__APOE__) ε4 allele is a risk factor for sporadic AD raises the possibility