No association of genetic variants of liver X receptor-β with alzheimer's disease risk
✍ Scribed by Eloy Rodríguez-Rodríguez; Javier Llorca; Ignacio Mateo; Jon Infante; Coro Sánchez-Quintana; Inés García-Gorostiaga; Carlos Fernández-Viadero; Nicolás Peña; José Berciano; Onofre Combarros
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 63 KB
- Volume
- 147B
- Category
- Article
- ISSN
- 1552-4841
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract A number of studies suggest that brain cholesterol metabolism may play a role in Alzheimer's disease (AD) development, probably through modulation of amyloid beta production. The discovery that apolipoprotein E (__APOE__) ε4 allele is a risk factor for sporadic AD raises the possibility
The -4 allele of apolipoprotein E (APOE) is associated with increased risk of Alzheimer's disease (AD), but the pathogenic mechanism is unknown. The 5-repeat allele of a CGG repeat polymorphism in the 5 untranslated region of the very low-density lipoprotein receptor (VLDL-R) gene, a receptor for ap
As the initial step in a systematic genome survey, 16 simple sequence tandem repeat polymorphisms that span the X chromosome at an average spacing of 10 cM were examined for allelic associations with typical-onset Alzheimer's disease (AD). The efficiency of this survey was substantially enhanced by