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Anxiety symptoms in mild cognitive impairment

✍ Scribed by Luca Rozzini; Barbara Vicini Chilovi; Matteo Peli; Marta Conti; Renzo Rozzini; Marco Trabucchi; Alessandro Padovani

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 73 KB
Volume: 24
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.2106

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Introduction

Anxiety disorders are less well studied in elderly people than other disorders such as depression. In particular the diagnosis of anxiety is more difficult in patients with
Mild Cognitive Impairment (MCI) since the current definition of MCI does not mention neuropsychiatric symptoms.

Objectives

To validate the Italian version of Geriatric Anxiety Inventory (GAI), an instrument that measures dimensional anxiety in elderly people, and assess whether MCI subjects with anxiety symptoms show different neuropsychological profiles in comparison with MCI without anxiety symptoms.

Methods

Fifty‐seven outpatients with MCI were consecutively recruited. All patients were assessed using a complete neuropsychological battery to detect the cognitive impairment, and the GAI for the presence of anxiety symptoms.

Results

Anxiety + patients (GAI ≥ 10) show more behavioral and psychological disturbances than patients with Anxiety‐ (GAI < 10); in particular they had more agitation, anxiety, depression and more sleep disorders. Moreover, Anxiety + patients are more compromised on instrumental daily functions and on executive functions evaluated with Trail Making B test (TMB). Linear Regression analysis was completed to estimate the coefficients of the linear equation, involving neuropsychological, psychobehavioural and functional characteristics: the executive functions (TMB) are the only variable independently related to the presence of anxiety disturbances.

Conclusions

Executive functions are independently related to anxiety disorders in MCI patients. We hypothesized that the strict interaction between anxiety symptoms and executive functions could depend on specific pathological features at the level of caudate nucleus characterizing early phases of dementia. Copyright © 2008 John Wiley & Sons, Ltd.

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