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The impact of anxiety on conversion from mild cognitive impairment to Alzheimer's disease

✍ Scribed by Deidre J. Devier; Gregory H. Pelton; Matthias H. Tabert; Xinhua Liu; Katrina Cuasay; Rachel Eisenstadt; Karen Marder; Yaakov Stern; D.P. Devanand

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
100 KB
Volume
24
Category
Article
ISSN
0885-6230

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✦ Synopsis

Abstract

Objective

To compare state and trait anxiety in mild cognitive impairment (MCI) patients and matched control subjects, and to assess the impact of these variables in predicting conversion to Alzheimer's disease.

Methods

One hundred and forty‐eight patients with MCI, broadly defined, were assessed and followed systematically. Baseline predictors for follow‐up conversion to AD (entire sample: 39/148 converted to Alzheimer's disease (AD)) included the Spielberger State‐Trait Anxiety Inventory (STAI).

Results

At baseline evaluation, MCI patients had higher levels of state and trait anxiety than controls, with no differences between future AD converters (n = 39) and non‐converters. In age‐stratified Cox proportional hazards model analyses, STAI State was not a significant predictor of conversion to AD (STAI State ≤30 vs. > 30 risk ratio, 1.68; 95% CI, 0.75, 3.77; p = 0.21), but higher Trait scores indicated a lower risk of conversion when STAI State, education, the Folstein Mini‐Mental State Examination and HAM‐D (depression score) were also included in the model (STAI Trait ≤30 vs. > 30 risk ratio, 0.36; 95% CI, 0.16, 0.82; p = 0.015).

Conclusions

In contrast to two other recent studies that showed anxiety predicted cognitive decline or conversion to AD, in this clinic‐based sample, state anxiety was not a significant predictor. However, higher Trait anxiety predicted a lower risk of future conversion to AD. Further research with systematic long‐term follow‐up in larger samples is needed to clarify the role of state and trait anxiety in predicting MCI conversion to AD. Copyright © 2009 John Wiley & Sons, Ltd.

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