Antiviral activity ofBifidobacterium adolescentisSPM0212 against Hepatitis B virus
✍ Scribed by Do Kyung Lee, Joo Yeon Kang, Hea Soon Shin, Il Ho Park…
- Book ID
- 120958889
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 422 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0253-6269
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Aucubin, an iridoid glycoside was found to suppress hepatitis B virus DNA replication in vitro in a 2.2.15 cell culture system. Aucubin itself did not exhibit antiviral activity, but it showed significant activity when preincubated with -glucosidase. Aucubin possesses no cytotoxicity at a broad ran
Various 2,3'-anhydro analogs of 5-substituted 1-(2-deoxy-β-d-lyxofuranosyl)uracils (10-15) and a related 1-(3-O-mesyl-2-deoxy-β-d-lyxofuranosyl) pyrimidine nucleoside analog (18) have been synthesized for evaluation as a new class of potential anti-HBV agents. The compounds 10, 12, and 15 demonstrat