OC-29 Antiviral activity of flavonoid-derived compounds against hepatitis B virus
β Scribed by Pollicino, T.; Musolino, C.; Bitto, A.; Raimondo, G.; Squadrito, F.; Altavilla, D.
- Book ID
- 123143251
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 55 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1590-8658
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Various 2,3'-anhydro analogs of 5-substituted 1-(2-deoxy-Ξ²-d-lyxofuranosyl)uracils (10-15) and a related 1-(3-O-mesyl-2-deoxy-Ξ²-d-lyxofuranosyl) pyrimidine nucleoside analog (18) have been synthesized for evaluation as a new class of potential anti-HBV agents. The compounds 10, 12, and 15 demonstrat
## Abstract Primary duck hepatocyte (PDH) cultures, congenitally infected with the duck hepatitis B virus (DHBV), were grown on feeder cell layers of irradiated human embryonic lung fibroblasts and then exposed to a number of compounds with recognized or potential antiviral activity. These compound