Antiviral activity of phosphatidyl-dideoxycytidine in hepatitis B-infected cells and enhanced hepatic uptake in mice
โ Scribed by Karl Y. Hostetler; Brent E. Korba; C.N. Sridhar; Michael F. Gardner
- Book ID
- 118393379
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 509 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0166-3542
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lipid prodrugs to target the liver may be useful in en-It would be desirable to develop antiviral agents that hancing antiviral therapy of hepatitis. (HEPATOLOGY can be targeted to liver to enhance their antiviral effects 1996;23:958-963.) and reduce nonhepatic toxicity. 2,3-Dideoxyguanosine (ddG) h
## Abstract Primary duck hepatocyte (PDH) cultures, congenitally infected with the duck hepatitis B virus (DHBV), were grown on feeder cell layers of irradiated human embryonic lung fibroblasts and then exposed to a number of compounds with recognized or potential antiviral activity. These compound