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Liver-targeted antiviral nucleosides: Enhanced antiviral activity of phosphatidyl-dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo

โœ Scribed by BA Korba; H Xie; KN Wright; WE Hornbuckle; JL Gerin; BC Tennant; KY Hostetler


Book ID
118686187
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
236 KB
Volume
23
Category
Article
ISSN
0270-9139

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Liver-targeted antiviral nucleosides: En
โœ B A Korba; H Xie; K N Wright; W E Hornbuckle; J L Gerin; B C Tennant; K Y Hostet ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 233 KB

lipid prodrugs to target the liver may be useful in en-It would be desirable to develop antiviral agents that hancing antiviral therapy of hepatitis. (HEPATOLOGY can be targeted to liver to enhance their antiviral effects 1996;23:958-963.) and reduce nonhepatic toxicity. 2,3-Dideoxyguanosine (ddG) h