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Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo

✍ Scribed by Zhu, Yuanxi; Zhang, Xiaobei; Liu, Yan; Zhang, Sheng; Liu, Jingjing; Ma, Yi; Zhang, Jin

Book ID
118302766
Publisher
S. Karger AG
Year
2012
Tongue
English
Weight
1004 KB
Volume
33
Category
Article
ISSN
1010-4283

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## Abstract Mammalian target of rapamycin (mTOR) is considered to be a major effector of cell growth and proliferation that controls protein synthesis through a large number of downstream targets. We investigated the expression of the phosphatidylinositol 3′‐kinase (PI3K)/mTOR signaling pathway in