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Antithrombotic and hemostatic capacity of factor Xa versus thrombin inhibitors in models of venous and arteriovenous thrombosis

✍ Scribed by Uma Sinha; Paul Ku; John Malinowski; Bing Yan Zhu; Robert M Scarborough; Charles K Marlowe; Paul W Wong; Pei Hua Lin; Stanley J Hollenbach


Book ID
114012991
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
439 KB
Volume
395
Category
Article
ISSN
0014-2999

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Antithrombotic effects of YM466, a synth
✍ Yoshiyuki Iwatsuki; Seiji Kaku; Yumiko Moritani; Yuta Taniuchi; Fukushi Hirayama πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 88 KB

## Abstract The antithrombotic effects of YM466, a synthetic direct inhibitor of human factor Xa (FXa), were evaluated in an arterio‐venous shunt thrombosis model in squirrel monkeys. YM466 significantly inhibited thrombus formation after continuous IV zx infusion at doses of 3–30 Β΅g/kg/h. Although