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Antithrombotic effects of YM-60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time

✍ Scribed by Kazuo Sato; Tomihisa Kawasaki; Nami Hisamichi; Yuta Taniuchi; Fukushi Hirayama; Hiroyuki Koshio; Yuzo Matsumoto


Book ID
110003345
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
316 KB
Volume
123
Category
Article
ISSN
0007-1188

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Antithrombotic effects of YM466, a synth
✍ Yoshiyuki Iwatsuki; Seiji Kaku; Yumiko Moritani; Yuta Taniuchi; Fukushi Hirayama πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 88 KB

## Abstract The antithrombotic effects of YM466, a synthetic direct inhibitor of human factor Xa (FXa), were evaluated in an arterio‐venous shunt thrombosis model in squirrel monkeys. YM466 significantly inhibited thrombus formation after continuous IV zx infusion at doses of 3–30 Β΅g/kg/h. Although