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Antithrombotic and anticoagulant effects of direct factor Xa inhibitor darexaban in rat and rabbit models of venous thrombosis

✍ Scribed by Kaku, Seiji; Uemura, Toshio; Saitoh, Minori; Suzuki, Ken-ichi; Iwatsuki, Yoshiyuki; Funatsu, Toshiyuki; Kawasaki, Tomihisa


Book ID
118252880
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
460 KB
Volume
699
Category
Article
ISSN
0014-2999

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Antithrombotic effects of YM466, a synth
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## Abstract The antithrombotic effects of YM466, a synthetic direct inhibitor of human factor Xa (FXa), were evaluated in an arterio‐venous shunt thrombosis model in squirrel monkeys. YM466 significantly inhibited thrombus formation after continuous IV zx infusion at doses of 3–30 Β΅g/kg/h. Although