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Antisense-mediated downregulation of anti-apoptotic proteins induces apoptosis and sensitizes head and neck squamous cell carcinoma cells to chemotherapy

✍ Scribed by H. Sharma; N. Singh


Book ID
118624832
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
105 KB
Volume
4
Category
Article
ISSN
1359-6349

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## Abstract ## Background. The p53 protein, a well‐known tumor suppressor that functions primarily as a transcription factor, initiates cell cycle arrest and apoptosis after genotoxic stress. The antiapoptotic regulator Bcl‐2 is a downstream modulator of p53‐induced apoptosis. Loss of function of