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An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins

✍ Scribed by Subramaniam, Aruljothi; Loo, Ser Yue; Rajendran, Peramaiyan; Manu, Kanjoormana A.; Perumal, Ekambaram; Li, Feng; Shanmugam, Muthu K.; Siveen, Kodappully Sivaraman; Park, Joo-In; Ahn, Kwang Seok; Hui, Kam M.; Kumar, Alan P.; Sethi, Gautam

Book ID: 121789802
Publisher: Springer
Year: 2013
Tongue: English
Weight: 798 KB
Volume: 18
Category: Article
ISSN: 1360-8185
DOI: 10.1007/s10495-013-0851-5

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## Abstract This article shows that HepG2, Hep3B, and SK‐Hep1 cells, three lines of human hepatocellular carcinoma (HCC) cells, are resistant to apoptosis induced by tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL). Parthenolide, a sesquiterpene lactone found in European feverfew, ha