Antisense Cyclin D1 Enhances Sensitivity of Head and Neck Cancer Cells to Cisplatin
β Scribed by Marilene B. Wang; Helena T. Yip; Eri S. Srivatsan
- Book ID
- 110082693
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 715 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0023-852X
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π SIMILAR VOLUMES
Cisplatin is a widely used chemotherapeutic agent in head and neck squamous cell carcinoma (HNSCC). Resistance to cisplatin is a common feature of HNSCC. To identify genes that may regulate cisplatin sensitivity, we carried out a cDNA microarray analysis of gene expression in cisplatin-sensitive and
Tunicamycin (TM), a naturally occurring antibiotic, blocks the first step in the biosynthesis of N-linked oligosaccharides in cells. In this study, we investigated whether changes in N-linked glycosylation affect the sensitivity of head-and-neck carcinoma cell lines to cis-diaminedichloroplatinum(II
## Abstract ## Background Cisplatin treatment is beneficial for approximately 20% of patients with head and neck squamous cell carcinoma (HNSCC). Tools to predict the clinical outcome and evaluate intrinsic cisplatin sensitivity are, therefore, required. ## Methods Cisplatin sensitivity, lysosom