Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin

Inhibition of N-linked glycosylation by

Inhibition of N-linked glycosylation by tunicamycin enhances sensitivity to cisplatin in human head-and-neck carcinoma cells

✍ Ichiro Noda; Shigeharu Fujieda; Mizue Seki; Nobuyuki Tanaka; Hiroshi Sunaga; Tos 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 155 KB 👁 2 views

Tunicamycin (TM), a naturally occurring antibiotic, blocks the first step in the biosynthesis of N-linked oligosaccharides in cells. In this study, we investigated whether changes in N-linked glycosylation affect the sensitivity of head-and-neck carcinoma cell lines to cis-diaminedichloroplatinum(II