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The effect of cyclin D1 overexpression in human head and neck cancer cells

✍ Scribed by Torahiko Nakashima; Yuichiro Kuratomi; Ryuji Yasumatsu; Muneyuki Masuda; Koji Koike; Toshiro Umezaki; Gary L. Clayman; Takashi Nakagawa; Shizuo Komune


Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
408 KB
Volume
262
Category
Article
ISSN
0302-9530

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## Abstract ## Background. Nuclear/cytoplasmic accumulation of β‐catenin is mainly regulated by its degradation, which is initiated by interaction with adenomatous polyposis coli (APC) protein. Accumulation of β‐catenin activates the transcription of 1 of the target oncogenic genes, cyclin D1, in