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Antipyretic effect of acetaminophen suppositories in rats

โœ Scribed by Albert Lock; Brenda McAllister Eckman; James Ayres

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
397 KB
Volume
68
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

An animal model used yeast-fevered rats to measure the relative antipyretic effects of different commercially available acetaminophen-containing suppositories. A laboratory-prepared acetaminophen-containing suppository and placebo suppositories also were investigated. Release from the suppositories was measured in vitro. All acetaminophen products containing 600 mg of drug elicited significant decreases in the rectal temperature of fever-induced rats.

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