✦ LIBER ✦

Influence of dosage form on antipyretic activity of acetaminophen administered intraperitoneally in the rat

✍ Scribed by Michael H. Stolar; Frederick Siegel; Ralph W. Morris

Publisher: John Wiley and Sons
Year: 1973
Tongue: English
Weight: 243 KB
Volume: 62
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600620240

No coin nor oath required. For personal study only.

✦ Synopsis

The relatively insoluble drug, acetaminophen, administered as a solution and injected intraperitoneally in rats, has been shown to produce an antipyretic response. approximately twice that of the same dose administered as a suspension. This experiment indicates that EDw, LDw, and relative potency calculations may be inaccurately determined if dosage form influences on biological availability of insoluble drugs are not considered in the design and evaluation of animal drug testing procedures.

Keyphrases 0 Acetaminophen-influence of dosage form on anti-

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