Antipyretic effect of Azadirachta indica in bacteria endotoxin induced fever in the rat

✍ Scribed by R. B. Ashorobi

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 98 KB
• Volume: 12
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(19980201)12:1<41::aid-ptr108>3.0.co;2-5

✦ Synopsis

Fever was induced in rats with a single i.p. injection of 30 g/kg E. coli endotoxin. The effect of the alcohol leaf extract of Azadirachta indica was investigated in this model. Pretreatment of rats with the leaf extract (125-375 mg/kg) did not significantly reduce endotoxin-induced fever. The rectal temperature remained significantly high. In contrast, administration of the same doses of the extract during the early phase of fever development (during temperature rise) produced a significant fall in the rectal temperature to near normal. The maximum rise was 1.0°C which later dropped to 0.18°C, and was sustained even beyond the experimental session. The data obtained suggest the beneficial antipyretic effect of the leaf extract of Azadirachta indica in bacteria endotoxin induced fever.