Antiparkinsonian activity of (+)-PHNO in the MPTP-treated common marmoset

✍ Scribed by M. Nomoto; S. Stahl; P. Jenner; Dr. C. D. Marsden

• Book ID: 102947123
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 542 KB
• Volume: 2
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.870020105

✦ Synopsis

Administration of MPTP (1-4 mg/kg ip daily for 5-7 days) to common marmosets induced persistent parkinsonian motor deficits. The subcutaneous administration of ( + )-PHNO [( + )-4-propyl-9-hydroxynaphthoxazine; 1-4 ~g / k g ] caused a dose-dependent reversal of the akinesia and incoordination of movement. Similarly, oral administration of (+ )-PHNO (5-20 pg/kg) caused an equivalent reversal of the motor abnormalities. No dyskinetic phenomena were induced by (+)-PHNO on oral or subcutaneous administration. Oral or subcutaneous administration of (+ )-PHNO to normal control marmosets also increased the usual repetoire of motor behaviour, but this was not as marked as in MPTP-treated animals. (+)-PHNO is a potent dopamine agonist drug of potential use in the treatment of Parkinson's disease.