## Abstract Overactive AMPA receptor‐mediated transmission may be involved in the pathogenesis of levodopa‐induced dyskinesia. The mechanism of action of the anticonvulsant drug topiramate involves attenuation of AMPA receptor‐mediated transmission. In this study, the potential antidyskinetic actio
Antiparkinsonian Actions of Ifenprodil in the MPTP-Lesioned Marmoset Model of Parkinson's Disease
✍ Scribed by J.E. Nash; S.H. Fox; B. Henry; M.P. Hill; D. Peggs; S. McGuire; Y. Maneuf; C. Hille; J.M. Brotchie; A.R. Crossman
- Book ID
- 115607309
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 73 KB
- Volume
- 165
- Category
- Article
- ISSN
- 0014-4886
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## Abstract In Parkinson's disease (PD), dyskinesia develops following long‐term treatment with 3,4‐dihydroxyphenylalanine (L‐dopa). Given the prominent role of the opioid system in basal ganglia function, nonselective opioid receptor antagonists have been tested for antidyskinetic efficacy in the
Administration of MPTP (1-4 mg/kg ip daily for 5-7 days) to common marmosets induced persistent parkinsonian motor deficits. The subcutaneous administration of ( + )-PHNO [( + )-4-propyl-9-hydroxynaphthoxazine; 1-4 ~g / k g ] caused a dose-dependent reversal of the akinesia and incoordination of mov