Antioxidant properties of extracts and compounds from Psoralea morisiana

✍ Scribed by Antonella Rosa; Monica Deiana; Giulia Corona; Angela Atzeri; Alessandra Incani; Giovanni Appendino; M. Assunta Dessì

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 118 KB
• Volume: 107
• Category: Article
• ISSN: 1438-7697
• DOI: 10.1002/ejlt.200501183

✦ Synopsis

Abstract

The antioxidant activity of various extracts (MeOH, petroleum ether, EtOAc) from the aerial parts of Psoralea morisiana, an endemic Sardinian plant, was evaluated during autoxidation and iron‐mediated oxidation of linoleic acid at 37 °C and during cholesterol oxidation at 140 °C, in the absence of solvent. The activity of erybraedin C, bitucarpin A and plicatin B, isolated from the extracts, was investigated under the same experimental conditions and compared to that of BHT and α‐tocopherol. All the extracts, erybraedin C (major constituent of the extracts) and plicatin B showed powerful antioxidant properties. None of the extracts and pure compounds showed any prooxidant activity. The cytotoxicity of the extracts, erybraedin C, and plicatin B was further evaluated in VERO cells, a line of fibroblasts derived from monkey kidney. Erybraedin C, at non‐cytotoxic concentrations, showed a strong inhibition of FeCl~3~‐induced oxidation in VERO cells.