Antimalarial preclinical drug development: a single oral dose of a 5-carbon-linked trioxane dimer plus mefloquine cures malaria-infected mice

✍ Scribed by Deuk Kyu Moon; Vandana Singhal; Nirbhay Kumar; Theresa A. Shapiro; Gary H. Posner

• Book ID: 102145547
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 121 KB
• Volume: 71
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.20350

✦ Synopsis

Abstract

Three new 5‐carbon‐linked trioxane dimer carboxylate esters have been prepared from the natural trioxane, artemisinin, in only three steps and 40–50% overall yields. Each one of these new chemical entities is at least as efficacious as the clinically used trioxane antimalarial drug artemether when combined with mefloquine hydrochloride in a low single oral dose cure. Drug Dev Res 71: 76–81, 2010. © 2009 Wiley‐Liss, Inc.