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A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice

✍ Scribed by Deuk Kyu Moon; Abhai Tripathi; David Sullivan; Maxime A. Siegler; Sean Parkin; Gary H. Posner


Book ID
104004956
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
300 KB
Volume
21
Category
Article
ISSN
0960-894X

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Antimalarial preclinical drug developmen
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## Abstract Three new 5‐carbon‐linked trioxane dimer carboxylate esters have been prepared from the natural trioxane, artemisinin, in only three steps and 40–50% overall yields. Each one of these new chemical entities is at least as efficacious as the clinically used trioxane antimalarial drug arte