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Antimalarial Activity of Cryptolepine and Some Other Anhydronium Bases

✍ Scribed by C. W. Wright; J. D. Phillipson; S. O. Awe; G. C. Kirby; D. C. Warhurst; J. Quetin-Leclercq; L. Angenot

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
252 KB
Volume
10
Category
Article
ISSN
0951-418X

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✦ Synopsis

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Phmodium falciparum (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitaemia was suppressed by 80% at 50 mg/kg/day.

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