Antiinflammatory profile of Tridax procumbens in animal and fibroblast cell models

✍ Scribed by I. Margaret; Reddy P. Srinivasa; Jamil Kaiser

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 73 KB
• Volume: 12
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199806)12:4<285::aid-ptr227>3.0.co;2-i

✦ Synopsis

The aqueous extract of Tridax procumbens leaves was lyophilized and studied on the excision wound model, rat skin fibroblast and rat paw oedema. Tridax procumbens did not significantly increase the fibroblast count compared with ibuprofen. Wound contraction was comparable in the Tridax and ibuprofen treated groups. Epithelialization was significant in the Tridax group. The aspirin treated group showed significant retardation in both parameters (p 0.001). The fibroblast cell count, hydroxyproline/ DNA ratio and collagen synthesis were insignificant in the control and Tridax treatment, while ibuprofen and aspirin treatment had a significant effect (p 0.01) on the above mentioned parameters. In the carageenin induced oedema model, inhibition of oedema was comparable in 200 mg/kg Tridax and 50 mg/kg ibuprofen treatment, and the specific activity of the enzyme gamma glutamyl transpeptidase was comparable in the Tridax, ibuprofen and aspirin at 200 mg/kg, groups.