Use of animal models in diagnosis and treatment of renal cell carcinoma

✍ Scribed by R. J. A. Moorselaar; J. A. Schalken; G. O. N. Oosterhof; F. M. J. Debruyne

• Publisher: Springer-Verlag
• Year: 1991
• Tongue: English
• Weight: 786 KB
• Volume: 9
• Category: Article
• ISSN: 0724-4983
• DOI: 10.1007/bf00182839

✦ Synopsis

This paper gives an overview of animal models available for the study of human renal cell carcinoma. Animal model systems can be divided into four categories: drug-induced tumors, virus-induced tumors, spontaneous tumors and human tumors transplanted into nude mice. Animal models have been used for improvement of diagnostic and therapeutic procedures. New markers for the diagnosis of more aggressive tumors can, for instance, be found by comparing metastatic with non-metastatic variants of the same primary tumor. Since advanced human renal cell carcinoma is refractory to chemotherapeutic agents, most therapeutic studies on animal models are immunotherapy studies. Combination treatment of biological-response modifiers such as interferon and tumor necrosis factor, with hyperthermia, bispecific monoclonal antibodies and high-energy shock waves, show promising results. Gene therapy will open new therapeutic possibilities.