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Antihypertensive agents III. Synthesis and antihypertensive activity of 3-[4-(p-fluoro-phenyl)-1,2,3,6-tetrahydro-1-pyridyl]-1-[1-(2-hydroxyethyl)-5-methyl-4-pyrazolyl]-1-propanone

✍ Scribed by V. P. Arya; R. S. Grewal; C. L. Kaul; S. P. Ghate


Book ID
112724590
Publisher
Springer
Year
1971
Tongue
English
Weight
234 KB
Volume
27
Category
Article
ISSN
1420-682X

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Synthesis of (R)-(+)-1,2,3,6-tetrahydro-
✍ I. Victor Ekhato; Che C. Huang πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 French βš– 371 KB πŸ‘ 1 views

1,2,3,6-Tetrahydr0-4-[U-1~C]phenylpyridine (12) was synthesized and coupled to (R)-3-phenyl-3-cyclohexene-1-carboxylic acid to make the titled compound 2 in 21% overall yield. Purification considerations were an important factor in the choice of a reaction sequence to 2, and successful synthesis was