Proceduresaredescribed forthe reverse phase HPLCanalysisof the antihorrnonal steroid ZK 98734 and two of its metabolites. Conditions are developed for the HPLC of the pure drug substance and for following its pharrnacokinetics and metabolism. Analysis conditions are also reported for the antiprogest
Antihormonal agents. Part 1: HPLC of RU 38486 and its metabolites
โ Scribed by Matlin, S. A. ;Abderabbani, N.
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 233 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0935-6304
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โฆ Synopsis
Procedures are described for the TLC and reverse phase HPLC analysis of the antihormonal steroid RU 38486 and its metabolites. Conditions are developed for the HPLC of the pure drug substance and a tablet formulation, and also for following its pharmacokinetics and metabolism.
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A simple, selective high-performance liquid chromatographic method with ultraviolet detection at 220 nm is described for quantitation of midazolam and its primary metabolite 1-hydroxymidazolam in 100 pL plasma samples from premature infants. A mobile phase of acetonitrile: tetrahydr0furan:phosphate