The glucocorticoid antagonist RU38486 mimics interleukin-1 in its sensitization to the lethal and interleukin-6-inducing properties of tumor necrosis factor

Interleukin-1β (IL-1β)-induced modulatio

Interleukin-1β (IL-1β)-induced modulation of the hypothalamic IL-1β system, tumor necrosis factor-α, and transforming growth factor-β1 mRNAs in obese (fa/fa) and lean (Fa/Fa) Zucker rats: Implications to IL-1β feedback systems and cytokine–cytokine interactions

✍ Carlos R. Plata-Salamán; Sergey E. Ilyin 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB 👁 1 views

## Interleukin -1␤ (IL-1␤) induces anorexia, fever, sleep changes, and neuroendocrine alterations when administered into the brain. Here, we investigated the regulation of the IL-1␤ system (ligand, receptors, receptor accessory protein, and receptor antagonist), tumor necrosis factor-␣ (TNF-␣), tr