## Abstract Complement fixation reactions were obtained with the use of cytoplasmic cellular constituents and sera from patients with S.L.E. as well as sera from cases of primary biliary cirrhosis and Sjogren's syndrome. These reactions were independent of those involving nuclear components. The se
Antigenic specificities of various antiribosomal antibodies detected in the serum of patients with systemic lupus erythematosus and other related diseases
β Scribed by M. T. Labro; A. Bryskier; Tan Huynh; J. C. Homberg
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 645 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0172-8172
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## Abstract Thirty patients with systemic lupus erythematosus (SLE( were studied over a 2.5βyear period. The group was divided into 14 patients with antibodies to Sm and a control group which failed to exhibit antibodies to Sm over the study period. The titer of antibodies to Sm fluctuated in all 1
A 96-well microplate ELISA for the detec-native E. coli DNA, calf thymus DNA, and tion of antibodies to DNA is described. A heat-denatured DNA. Using native E. coli number of buffers and precoating treat-DNA, virtually none of 35 normal sera had ments were used to evaluate the optimal any detectable
Two common cross-reacting anti-DNA antibody idiotypes designated 1616 and 32/15, previously identified in the serum of patients who have systemic lupus erythematosus, were found in 24% and 7%, respectively, of 147 first-degree relatives. These findings imply that high-frequency germ-line genes exist