Presentation of antigenic peptides by MHC class II molecules to CD4(+) T cells requires many events in both the biosynthetic and endocytic pathways that must all occur in a controlled and coordinated fashion. In recent years the roles of two important chaperones, the invariant chain and the HLA-DM d
Antigen Presentation: MHC class II trafficking
โ Scribed by Bell, Elaine
- Book ID
- 109957781
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 157 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1474-1741
- DOI
- 10.1038/nri899
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The MHC class II molecules have been recognized as signaling receptors for more than a decade, and recent work has revealed the importance of their signaling for the immune response. Today, we know that the function of MHC class II molecules on antigen-presenting cells (APCs) is not limited to their
Particularly prominent during the past year was the analysis of the subcellular compartment in which MHC class II molecules are located. Some investigators also analyzed the site where peptides are generated for MHC class II binding. Studies of invariant chain were particularly important in trying t