Antigen Presentation: Getting peptides into MHC class II molecules
โ Scribed by Peter Cresswell
- Book ID
- 114317337
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 370 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0960-9822
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Particularly prominent during the past year was the analysis of the subcellular compartment in which MHC class II molecules are located. Some investigators also analyzed the site where peptides are generated for MHC class II binding. Studies of invariant chain were particularly important in trying t
Presentation of antigenic peptides by MHC class II molecules to CD4(+) T cells requires many events in both the biosynthetic and endocytic pathways that must all occur in a controlled and coordinated fashion. In recent years the roles of two important chaperones, the invariant chain and the HLA-DM d