The concentration of a novel anticonvulsant, 2,3 : 4,5-bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamate (topiramate), was determined in the extracellular Ñuid of rat brain by in vivo microdialysis combined o †-line with liquid chromatography/thermospray mass spectrometry. A microdialysis prob
✦ LIBER ✦
Anticonvulsant Effect of Topiramate [2, 3:4, 5-bis-O-(1-methylethylidene-β-D-fructopyranose sulfate] on Amygdaloid Kindled Seizures in the Cat
✍ Scribed by Fumihiro Nakamura; Toshio Hiyoshi; Tatsuya Kudo; Kazuichi Yagi; Masakazu Seino
- Book ID
- 118708998
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 147 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1323-1316
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Topiramate, a sulfamate-substituted monosaccharide (2,3:4,5-bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamate), is a new antiepileptic drug, which has been approved for adjunctive therapy in adult patients with partial-onset seizures. Liquid-liquid extraction followed by flow-injection negativ