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Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats

✍ Scribed by Yutaka Kitano; Chika Komiyama; Mitsuhiro Makino; Kiyoshi Takasuna; Hiroshi Satoh; Takashi Aoki; Masakazu Kinoshita; Akira Takazawa; Toshio Yamauchi; Shinobu Sakurada

Book ID
113500855
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
561 KB
Volume
1057
Category
Article
ISSN
0006-8993

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## Abstract Kainic acid (KA)‐induced status epilepticus (SE) is a well‐characterized model of excitotoxic neuronal injury. Excitotoxicity results from activation of specific glutamate receptors, with resultant elevation of intracellular Ca^2+^. The CA1 and CA3 subregions of the hippocampus are espe