Effects of Nefiracetam, a Novel Pyrrolidone-type Nootropic Agent, on the Amygdala-kindled Seizures in Rats
β Scribed by Yutaka Kitano; Chika Komiyama; Mitsuhiro Makino; Yoshio Kasai; Kiyoshi Takasuna; Masakazu Kinoshita; Osamu Yamazaki; Akira Takazawa; Toshio Yamauchi; Shinobu Sakurada
- Book ID
- 109108480
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2005
- Tongue
- English
- Weight
- 232 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0013-9580
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## Abstract Kainic acid (KA)βinduced status epilepticus (SE) is a wellβcharacterized model of excitotoxic neuronal injury. Excitotoxicity results from activation of specific glutamate receptors, with resultant elevation of intracellular Ca^2+^. The CA1 and CA3 subregions of the hippocampus are espe