Anticipation and CAG•CTG repeat expansion in schizophrenia and bipolar affective disorder
✍ Scribed by M. Teresa Fortune; James L. Kennedy; John B. Vincent
- Book ID
- 107551568
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 586 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1523-3812
No coin nor oath required. For personal study only.
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The hypothesis that expanded trinucleotide repeats contribute to the pathogenesis of schizophrenia and bipolar disorder has been recently supported by three independent studies which have shown that patients with either disorder tend to have larger CAG/CTG repeat expansion detection products than co
A decrease in age of onset of schizophrenia through consecutive family generations (anticipation) has been found in several studies. Anticipation is known to result from expansion of CAG repeats in genes that determine several neurodegenerative disorders. In a previous study we analysed 26 unilineal
## Abstract The possible presence of anticipation in bipolar affective disorder and schizophrenia has led to the hypothesis that repeat expansion mutations could contribute to the genetic etiology of these diseases. Using the repeat expansion detection (RED) assay, we have systematically examined g