Anticipation and repeat expansion in bipolar disorder
β Scribed by O'Donovan, Michael ;Jones, Ian ;Craddock, Nick
- Book ID
- 101453996
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 99 KB
- Volume
- 123C
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
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Anticipation was investigated in schizophrenia (SZ) and bipolar disorder (BP) while addressing several biases in 18 large families (154 subjects) from Eastern Que Β΄bec densely affected by SZ, BP, or both over three generations. In particular, we controlled for an information bias using a measure of
Anticipation has been suggested among the genetic mechanisms of bipolar disorder (BD), prompting the search for unstable DNA sequences. Past studies of anticipation in BD have generally relied on observed shift in the age at onset between parental and offspring generations. Such a shift, however, ma