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Anticandidal properties of N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid oligopeptides

✍ Scribed by Andruszkiewicz, Ryszard; Milewski, Slawomir; Zieniawa, Teresa; Borowski, Edward


Book ID
120601594
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
586 KB
Volume
33
Category
Article
ISSN
0022-2623

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Glucosamine synthase (E.C. 2.6.1.16) is a promising target in antifungal drug design. It has been reported that its potent inhibitor, N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), inactivates the enzyme by the Michael addition of the S-H group to the FMDP molecule followed by cyclisatio