Synthesis of N3-fumaramoyl-L-2,3-diaminopropanoic acid analogues, the irreversible inhibitors of glucosamine synthetase
β Scribed by ANDRUSZKIEWICZ, RYSZARD ;CHMARA, HENRYK ;MILEWSKI, SLAWOMIR ;BOROWSKI, EDWARD
- Book ID
- 115098414
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 356 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0367-8377
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π SIMILAR VOLUMES
Glucosamine synthase (E.C. 2.6.1.16) is a promising target in antifungal drug design. It has been reported that its potent inhibitor, N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), inactivates the enzyme by the Michael addition of the S-H group to the FMDP molecule followed by cyclisatio
## Abstract Amino acids with __N__βalkylaminooxy side chains have proven effective for the rapid synthesis of neoglycopeptides. Chemoselective reaction of reducing sugars with peptides containing these amino acids provides glycoconjugates that are structurally similar to their natural counterparts.