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N3-haloacetyl derivatives of l-2,3-diaminopropanoic acid: Novel inactivators of glucosamine-6-phosphate synthase

✍ Scribed by Milewski, Słwomir; Chmara, Henryk; Andruszkiewicz, Ryszard; Borowski, Edward

Book ID: 122652749
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 355 KB
Volume: 1115
Category: Article
ISSN: 0304-4165
DOI: 10.1016/0304-4165(92)90058-3

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Glucosamine synthase (E.C. 2.6.1.16) is a promising target in antifungal drug design. It has been reported that its potent inhibitor, N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), inactivates the enzyme by the Michael addition of the S-H group to the FMDP molecule followed by cyclisatio